Update on ranolazine in the management of angina
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چکیده
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Update on ranolazine in the management of angina
Mortality rates attributable to coronary heart disease have declined in recent years, possibly related to changes in clinical presentation patterns and use of proven secondary prevention strategies. Chronic stable angina (CSA) remains prevalent, and the goal of treatment is control of symptoms and reduction in cardiovascular events. Ranolazine is a selective inhibitor of the late sodium current...
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Chronic angina represents a major burden for public health systems because of its poor prognosis and its high treatment costs. Ranolazine is an emerging drug recently approved for the treatment of this disease. The main molecular mechanism underlying ranolazine-mediated beneficial effects has been identified as inhibition of the late Na+ current during the action potential, which potentially im...
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ژورنال
عنوان ژورنال: Vascular Health and Risk Management
سال: 2014
ISSN: 1178-2048
DOI: 10.2147/vhrm.s40477